The August 2019 Windows Updates includes .Net 4.8, however most BizTalk versions only support specific version of .Net, and installing a unsupported version of .Net has caused issues in the past. So if you are patching BizTalk servers, make sure to block installing any unsupported .Net Version.
Important: If the wrong version of .Net get’s installed and it breaks BizTalk, make sure you back up the machine.config files (32 and 64 bit) BEFORE you uninstall the incorrect .NET version and re-install the correct version as you will need to re-add those settings. Also removing and re-adding .Net might cause all your application pools to default to .Net v2.0 and you need to set them back to v4.0
| BizTalk Version | Minimum .Net version | Maximum .Net version | Link |
| BizTalk 2020 | .NET 4.7.2 | Hardware and Software Requirements for BizTalk Server 2020 | |
| BizTalk 2016 | .Net 4.6.x | .Net 4.7.2 with CU2 4.8 with CU7 | Hardware and Software Requirements for BizTalk Server 2016 (Response on SFTP Adapter does not retain settings, does not delete files) |
| BizTalk 2013 R2 | .Net 4.5.x | .Net 4.6.x | Hardware and Software Requirements for BizTalk Server 2013 and 2013 R2 |
| BizTalk 2013 | .Net 4.5.x | .Net 4.5.x | Hardware and Software Requirements for BizTalk Server 2013 and 2013 R2 |
| BizTalk 2010 | .Net 3.5 with SP1 | .Net 4.5 with CU7 | Comparison of Software Requirement of different versions of BizTalk Servers |
| BizTalk 2009 | .Net 3.5 with SP1 | Comparison of Software Requirement of different versions of BizTalk Servers | |
| BizTalk 2006 R2 | .Net 1.1 & .Net 2 | .Net 3.0 | [PDF] BizTalk Server 2006 R2 System Requirements – Microsoft |
How to block the installation
- How to temporarily block installation of the .NET Framework 4.7
- How to temporarily block the installation of .NET Framework 4.8
BizTalk musings 
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