New Update:   As this issue re-occurred, we applied to fix as per Randy Ridgely in this thread: Microsoft Security Updates cause BizTalk Admin Console errors: An internal failure occurred for unknown reasons (WinMgmt) 


This issue is supposedly resolved in August 2018 .NET Framework Security and Quality Rollup

An update on my earlier blog post An internal failure occurred for unknown reasons (WinMgmt)

Below are the KB numbers for the monthly rollups and security only patches that have impacted or could impact various version of BizTalk Admin Console on different operating systems as per the Technet thread, Sandro’s blog, Stack Overflow and Twitter.

Sandro’s blog also describes the steps for uninstalling.

Monthly Rollup Security Only .Net OS BizTalk
KB4338415 KB4338600  .NET Framework 4.5.2 Windows 8.1, RT 8.1, and Server 2012 R2 BT2010-2013R2
KB4338416 KB4338601 .NET Framework 4.5.2 Windows Server 2012 BT2010-2013R2
KB4338417 KB4338602 .NET Framework 4.5.2 Windows 7 SP1, Server 2008 R2 SP1, and Server 2008 BT2010-2013R2
KB4338815 .NET Framework 4.5.2 Windows RT 8.1, Windows 8.1, and Windows Server 2012 R2 BT2010-2013R2
KB4284833 OS Build 14393.2339 Windows Server 2016 BT2016
KB4338419 KB4338605 .NET Framework 4.6, 4.6.1, 4.6.2, 4.7, 4.7.1 and 4.7.2 Windows 8.1, RT 8.1, and Server 2012 R2 BT2016
KB4338814 OS Build 14393.2363 Windows 10,  (but also reported on Windows Server 2016 on twitter/technet) BT2016
KB4345418 OS Build 14393.2368 Windows Server 2016 BT2016
Also reported but probably not an issue
KB4338613 .NET Framework 3.5 SP1 Windows 8.1, RT 8.1, and Server 2012 R2
KB4338614 ? Probably a Typo for 4338814, as does not exist
KB4338424 NET Framework 3.5 SP1 Windows Server 2016 BT2016

The CVE’s in question which these KBs are addressing are:

Microsoft has published a blog post Advisory on July 2018 .NET Framework Updates and the following KB about the issue. “Access Denied” errors and applications with COM activation fail after installing July 2018 Security and Quality Rollup updates for .NET Framework