New Update: As this issue re-occurred, we applied to fix as per Randy Ridgely in this thread: Microsoft Security Updates cause BizTalk Admin Console errors: An internal failure occurred for unknown reasons (WinMgmt)
Update: This issue is supposedly resolved in August 2018 .NET Framework Security and Quality Rollup
An update on my earlier blog post An internal failure occurred for unknown reasons (WinMgmt)
Below are the KB numbers for the monthly rollups and security only patches that have impacted or could impact various version of BizTalk Admin Console on different operating systems as per the Technet thread, Sandro’s blog, Stack Overflow and Twitter.
Sandro’s blog also describes the steps for uninstalling.
| Monthly Rollup | Security Only | .Net | OS | BizTalk |
| KB4338415 | KB4338600 | .NET Framework 4.5.2 | Windows 8.1, RT 8.1, and Server 2012 R2 | BT2010-2013R2 |
| KB4338416 | KB4338601 | .NET Framework 4.5.2 | Windows Server 2012 | BT2010-2013R2 |
| KB4338417 | KB4338602 | .NET Framework 4.5.2 | Windows 7 SP1, Server 2008 R2 SP1, and Server 2008 | BT2010-2013R2 |
| KB4338815 | .NET Framework 4.5.2 | Windows RT 8.1, Windows 8.1, and Windows Server 2012 R2 | BT2010-2013R2 | |
| KB4284833 | OS Build 14393.2339 | Windows Server 2016 | BT2016 | |
| KB4338419 | KB4338605 | .NET Framework 4.6, 4.6.1, 4.6.2, 4.7, 4.7.1 and 4.7.2 | Windows 8.1, RT 8.1, and Server 2012 R2 | BT2016 |
| KB4338814 | OS Build 14393.2363 | Windows 10, (but also reported on Windows Server 2016 on twitter/technet) | BT2016 | |
| KB4345418 | OS Build 14393.2368 | Windows Server 2016 | BT2016 | |
| Also reported but probably not an issue | ||||
| KB4338613 | .NET Framework 3.5 SP1 | Windows 8.1, RT 8.1, and Server 2012 R2 | ||
| KB4338614 | ? | Probably a Typo for 4338814, as does not exist | ||
| KB4338424 | NET Framework 3.5 SP1 | Windows Server 2016 | BT2016 | |
The CVE’s in question which these KBs are addressing are:
Microsoft has published a blog post Advisory on July 2018 .NET Framework Updates and the following KB about the issue. “Access Denied” errors and applications with COM activation fail after installing July 2018 Security and Quality Rollup updates for .NET Framework
BizTalk musings 
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